2007 - STRETTA CLINICAL Improvement of objective GERD parameters after radiofrequency energy delivery: A European study
Peter N. Meier, Tina Nietzschmnn, Ibrahim Akin, Stefanie Klose, and Michael P. Manns
Scandinavian Journal of Gastroenterology, 2007; 42: 911-916
OBJECTIVE: The Stretta procedure is an endoluminal radiofrequency energy delivery system for the treatment of gastroesophageal reflux disease (GERD). The purpose of this study was to present, for the first time, the Stretta treatment experience from European centers.
MATERIAL AND METHODS: Sixty patients with a history of GERD from six European centers underwent Stretta treatment from May 2001 to June 2003. All patients were at least partly responsive to daily proton-pump inhibitors. Esophageal motility, endoscopy, and ambulatory 24-h pH studies were done in all patients at baseline and 6 and 12 months after treatment. We evaluated medication use, satisfaction, GERDhealth- related quality of life, 24-h pH-metry, manometry, and endoscopy.
RESULTS: Sixty patients (31 M, 29 F, mean age 47 +/13 years, mean years of GERD 7.49/+ 7.2) were treated with the Stretta procedure. At 12 months after treatment, 75% of the patients needed no medication or less medication than before treatment. They were more satisfied with their symptom control and had statistically significantly fewer GERD symptoms (mean lower esophageal sphincter (LES) pressure improved from 14.8 +/9.1 to 16.7 +/10.0 mmHg, p=0.002 and mean total reflux time from 16.7 +/12.8 to 8.8 +/6.6%, p=0.001). Quality of life (mean score decreased from 19.2 +/9.0 to 6.6 +/7.3, p </0.0001) and overall physical and mental health also improved significantly.
CONCLUSIONS: The experience with the Stretta procedure performed at centers in Europe confirms that it is well tolerated and effective in the treatment of GERD. It has a favorable impact on medication requirements, LES pressure, esophageal acid exposure, and GERD symptom scores. The Stretta procedure should be considered for patients who are not satisfied with drug therapy, and who are considering anti-reflux surgery.